Don't Jump to a CGRP Antagonist for Migraine Prophylaxis

December 2018

You'll see two new biologics to PREVENT migraine in adults, Ajovy (uh-JOH-vee, fremanezumab) and Emgality (em-GAL-ih-tee, galcanezumab).

They'll join Aimovig (erenumab)...the first calcitonin gene-related peptide blocker, or CGRP antagonist. Blocking CGRP limits vasodilation.

All are once-monthly, self-administered subcutaneous injections...or Ajovy can be given as 3 injections once every 3 months. Aimovig is an auto-injector...Ajovy is a prefilled syringe...Emgality is a pen.

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