St. John's wort might reduce the effectiveness of oral contraceptives
June 2000
There are growing concerns that St. John's wort might reduce the effectiveness of oral contraceptives.
So far there are reports of breakthrough bleeding and menstrual irregularities in women who combine St. John's wort and the pill. These are signs of decreased estrogen levels.
St. John's wort appears to induce cytochrome P450 3A4...which increases the metabolism of ethinyl estradiol.
Get concise advice on drug therapy, plus unlimited access to CE
Pharmacist's Letter membership benefits include:
- 12 issues every year — what you need to know and do, right now
- Quick, practical reference charts and tools
- Comprehensive CE library to meet license renewal and state requirements
- Multiple course formats including live webinars, podcasts, and CE-in-the-Letter to match your learning style
- Plus much more!
Choose the right tier for your needs today.
Already a subscriber? Log in
Volume pricing available. Get a quote