ibuprofen reduces the effectiveness of aspirin
March 2003
Patients are hearing that ibuprofen reduces the effectiveness of aspirin...and increases the risk of heart attack and stroke.
This stems from a new study that suggests people who take their daily low-dose aspirin with ibuprofen have almost DOUBLE the risk of dying from cardiovascular disease.
Both aspirin and ibuprofen bind COX-1 to inhibit platelet aggregation. The theory is that if ibuprofen binds COX-1 first, it will block aspirin's antiplatelet effects.
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