more reports of rhabdomyolysis in patients taking both simvastatin and amiodarone (Cordarone, etc)

October 2008

The FDA is getting more reports of rhabdomyolysis in patients taking both simvastatin and amiodarone (Cordarone, etc).

Package inserts already have a warning about muscle injury with this combo...but it keeps happening.

Amiodarone inhibits CYP3A4, which increases concentrations of simvastatin...lovastatin...and to a lesser extent, atorvastatin.

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