whether hydrochlorothiazide should be used first-line for hypertension

March 2011

There's new controversy about whether hydrochlorothiazide should be used first-line for hypertension.

Hydrochlorothiazide is the most commonly used antihypertensive...and most prescribers give just 12.5 to 25 mg/day to reduce side effects.

But new evidence suggests that these LOW doses reduce ambulatory BP less than ACEIs, ARBs, calcium channel blockers, or beta-blockers.

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