whether citalopram (Celexa, etc) can be used with oral contraceptives or PPIs

January 2012

We're getting questions about whether citalopram (Celexa, etc) can be used with oral contraceptives or PPIs.

FDA recommends using lower citalopram doses when it's combined with 2C19 inhibitors, such as cimetidine or omeprazole. These can inhibit citalopram metabolism and increase the risk of arrhythmias.

This brings up questions about whether lower citalopram doses are also needed with other PPIs or oral contraceptives.

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