new warnings that PPIs (omeprazole, etc) might increase the risk of Clostridium difficile-associated diarrhea

March 2012

You'll see new warnings that PPIs (omeprazole, etc) might increase the risk of Clostridium difficile-associated diarrhea.

FDA is on this now. C. diff seems to be more common in PPI users...probably because increasing stomach pH allows C. diff to grow more easily.

Keep C. diff in mind if a patient on a PPI complains of watery diarrhea, abdominal pain, and fever...especially after recent antibiotic use. Tell them this needs to be checked right away.

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