Suggest Fluoxetine Instead of Paroxetine for a More Weight-Neutral SSRI

April 2015

New obesity guidelines will increase awareness about medications that can lead to significant weight gain...and possible alternatives.

Atypical antipsychotics. These are some of the worst offenders...especially olanzapine (Zyprexa, etc) or clozapine. About one-third of patients using olanzapine gain more than 7% of their original body weight.

Explain that weight gain is less likely with aripiprazole (Abilify), paliperidone (Invega), lurasidone (Latuda), asenapine (Saphris), or ziprasidone (Geodon, etc).

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